Incorporating graphene oxide and Cu nanoparticles to alter PVA based nanofibers through adding curcumin with high antibacterial activities used in wound healing
1School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran
2Department of Life Science Engineering, Faculty of New Science and Technology, University of Tehran, Tehran, Iran
3Department of Chemical Engineering, Faculty of Engineering, University of Tehran, Tehran, Iran
چکیده
The main purpose of this study is the optimization and fabrication of bacterial cellulose-based on GO-Cu-Cur nanocomposite and PVA/GO-Cu-Cur as a wound dresser in order to accelerate the wound repairing process. First of all, graphene oxide, GO-Cu nanohybrid, and GO-Cu-Cur nanohybrid were synthesized, and by the were characterized. Then, the PVA/GO-Cu-Cur was synthesized by the electrospinning method, and by the FTIR was characterized. SEM analysis indicates that the diameter of the nanofibers is 328 nm. Mechanical characteristic of PVA/GO-Cu-Cur was investigated by the tensile resistance, and it reveals that the GO-Cu-Cur nanohybrid cause the improvement of mechanical characteristic. The bacterial cellulose/GO-Cu-Cur by the floating method was synthesized, and also, the biodegradable behavior of nanocomposite was optimized, and the sample shows a degradation percentage of 44% after 98 h. For investigation of the antibacterial effect of synthesized materials, the MIC and optical density (OD) were used. The results show that these materials have a great ability to inhibition of gram-negative and gram-positive bacteria growth. The toxicity, survival, and cell proliferation of the fibroblast cells by the MTT were investigated, and results show that the GO-Cu-Cur nanohybrid does not have a toxic effect. Therefore, the PVA/GO-Cu-Cur nanofiber is a promising wound dressing for inhibiting bacterial growth and promoting skin wound repair
